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KMID : 0644120040170010088
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Journal of Oriental Gynecology
2004 Volume.17 No. 1 p.88 ~ p.110
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Effects of Kaewooljongoktang on Serum Levels of Hormone and Immune Response after Immobilization Stress in Mice
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Kim Deok-Nim
Cho Han-Baek
Yoo Sim-Keun
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Abstract
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The purpose of this research was to investigate the effects of Kaewooljongoktang water extract (KJT) on immobilization stress in C57BL/6J mice. KJT decreased the serum level of histamine and corticosterone increased by immobilization stress. In addition, KJT enhanced the cell viability of thymocytes and splenocytes decreased by immobilization stress. Also, KJT increased the viability of thymocytes and did not affect the viability of splenocytes in vitro. KJT did not affect DNA fragmentation of thymocytes and decreased DNA fragmentation of splenocytes increased by immobilization stress. KJT did not affect the population of thymic CD4+ cells increased by immobilization stress, and increased the population of B220+ cells decreased by immobilization stress and increased the population of splenic CD4+ cells increased by immobilization stress. KJT enhanced the production of -interferon, IL-2 and IL-4 decreased by immobilization stress. Also, KJT enhanced the phagocytic activity decreased by immobilization stress and enhanced the level of nitric oxide decreased by immobilization stress. These results indicate that KJT may be useful for the prevention and treatment of stress via suppression of serum histamine and corticosterone level and enhancement of specific- and nonspecific-immune response.
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KEYWORD
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Kaewooljongoktang(KJT), immobilization stress, histamine, corticosterone, thymocytes, splenocytes, phagocytic activity, immune response
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